Meta: insuliinin erityksen alentaminen lääkkeillä pudotti painoa, ja vieläpä oikeasta paikasta eli jättäen rasvattoman massan ennalleen, mutta nosti verensokeria.
Suppression of Insulin Secretion in the Treatment of Obesity: A Systematic Review and Meta‐AnalysisLainaa:
Results
A total of seven randomized controlled trials were included, with four using diazoxide and three using octreotide to suppress insulin secretion. Suppression of insulin secretion significantly reduced fasting insulin level (mean difference: −3.94 mIU/L; 95% CI: −7.40 to −0.47) but slightly increased fasting blood glucose level (mean difference: 0.48 mmol/L; 95% CI: 0.24 to 0.72). Following the suppression of insulin secretion, significant reductions in body weight (mean difference: −3.19 kg; 95% CI: −5.71 to −0.66), BMI (mean difference: −1.65 kg/m2; 95% CI: −2.41 to −0.90), and fat mass (mean difference: −5.92 kg; 95% CI: −8.28 to −3.56) were observed compared with placebo in the pooled data. No significant difference in fat‐free mass was observed (mean difference: 0.56 kg; 95% CI: −0.40 to 1.52).
Conclusions
Results suggest that suppression of insulin secretion may lead to reduced body weight and fat mass with slightly increased blood glucose in individuals with obesity.
KuNpa meillä olisi jokin keino, jolla voisi vähentää insuliinin eritystä ilman että verensokeri nosusee.
Ai niin, onhan meillä vhh/keto.