karppaus.info

The American Journal of Clinical Nutrition
Available online 8 April 2024
In Press, Journal Pre-proof
The American Journal of Clinical Nutrition
Plant-based meat analogues (PBMAs) and their effects on cardiometabolic health: An 8-week randomized controlled trial comparing PBMAs with their corresponding animal-based foods☆

https://doi.org/10.1016/j.ajcnut.2024.04.006

Abstract
Background
With the growing popularity of plant-based meat analogues (PBMAs), an examination of their effects on health is warranted in an Asian population.

Objective
This research investigated the impact of consuming an omnivorous animal-based meat diet (ABMD) compared to a PBMAs diet (PBMD) on cardiometabolic health among adults with elevated risk of diabetes in Singapore.

Methods
In an 8-week parallel design randomized controlled trial, participants (n=89) were instructed to substitute habitual protein-rich foods with fixed quantities of either PBMAs (n=44) or their corresponding animal-based meats (n=45; 2.5 servings daily) maintaining intake of other dietary components. LDL-cholesterol served as primary outcome, while secondary outcomes included other cardiometabolic disease-related risk factors (e.g. glucose, fructosamine), dietary data, and within a sub-population, ambulatory blood pressure measurements (n=40) at baseline and post-intervention, as well as a 14-day continuous glucose monitor (glucose homeostasis-related outcomes; n=37).

Results
Data from 82 participants (ABMD:42, PBMD:40) were examined. Using linear mixed-effects model, there were significant interaction (time × treatment) effects for dietary trans-fat (increased in ABMD), dietary fiber, sodium and potassium (all increased in PBMD; PInteraction<0.001). There were no significant effects on the lipoprotein profile, including LDL-cholesterol. Diastolic blood pressure (DBP) was lower in the PBMD group (PInteraction=0.041) although the nocturnal DBP markedly increased in ABMD (+3.2% mean) and was reduced in PBMD (-2.6%; PInteraction=0.017). Fructosamine (PTime=0.035) and homeostatic model assessment for β-cell function were improved at week 8 (PTime=0.006) in both groups. Glycemic homeostasis was better regulated in the ABMD than PBMD groups as evidenced by interstitial glucose time in range (ABMD median: 94.1% (Q1:87.2%, Q3:96.7%); PBMD: 86.5% (81.7%, 89.4%); P=0.041). The intervention had no significant effect on the other outcomes examined.

Conclusions
A plant-based meat analogues diet did not show widespread cardiometabolic health benefits compared with omnivorous diets over 8 weeks. The composition of PBMAs may need to be considered in future trials.

Vegan Impossible burgers increase risk of diabetes and heart problems - new study finds you're better off with REAL meat

Study showed that people who eat plant-based meats had higher blood sugar
This could be a sign that they are more likely to develop heart disease
READ MORE: Animal proteins are crucial for healthy aging, major study shows

PUBLISHED: 11 April 2024

They're said to be low in fat, good for cholesterol and an overall healthier choice than the real deal.

But a new trial suggests that plant-based fake meat products are not in fact a nutritious choice - and could increase the risk of heart disease.

The study, published in the American Journal of Clinical Nutrition, found that people who ate a diet high in fake meats like Beyond burgers and Impossible burgers for eight weeks had higher blood sugars than those who ate real meat.

This puts them at higher risk for developing heart disease and diabetes down the line, the authors wrote.